Some Recent NIH-Funded Experiments on Animals Conducted in Foreign Laboratories

Institution conducting experiment, country, funding agency, and award Grant or published paper What experimenters do/did to animals
Kinoxis Therapeutics, Australia National Institute on Drug Abuse 2023: $2,149,117 Advancing KNX100 for the treatment of opioid withdrawal: preclinical efficacy and toxicology, and a phase 1 clinical program. [Grant] Experimenters addict dogs to opioids.
University of Prince Edward Island, Canada National Institute of Neurological Disorders and Stroke 2023: $138,116 Early-life seizures modify behavioral response to ultrasonic vocalization playback in adult rats. Epilepsy Behav. 2022 Experimenters injected acid into the brains of baby rats to induce seizures.
University of Calgary, Canada National Institute of Allergy and Infectious Diseases 2023: $602,472 Utility of hybrid transferrin binding protein antigens for protection against pathogenic neisseria species. Front Immunol. 2019 Experimenters infected 48 female mice with gonorrhea and 32 male mice with bacterium that cause meningitis.
University of Melbourne, Australia National Institute of Diabetes and Digestive and Kidney Diseases 2023: $321,387 Sex differences in c‐Fos and EGR‐1/Zif268 activity maps of rat sacral spinal cord following cystometry‐induced micturition. J. Comp. Neurol. 2021 Experimenters surgically implanted catheters in the bladders of 24 rats, then infused saline solution into the bladders to force the animals to urinate constantly.
Commonwealth Scientific and Industrial Research Organization, Australia National Institute of Allergy and Infectious Diseases 2023: $146,098 Shining a light on bat cellular immunity following virus infection. [Grant] Experimenters infect bats with a highly harmful virus.
University of Sydney, Australia National Institute of Allergy and Infectious Diseases 2022: $2,453,560 Advancing vaccine adjuvant research for tuberculosis (Avart-t). [Grant] Experimenters infect monkeys with tuberculosis.
Newcastle University, U.K. National Institute of Neurological Disorders and Stroke 2023: $457,675 Locating the neural substrates for the flexor synergy after stroke. [Grant] Experimenters surgically implant electrodes in monkeys’ arms and then damage their brains to strokes.
McGill University, Canada National Institute on Deafness and Other Communication Disorders 2023: $492,583 Functional analysis of injectable substance treatment on surgically injured rabbit vocal folds. J. Voice. 2021 Experimenters cut the vocal cords of 12 rabbits and inserted a spatula “several times to exacerbate inflammation and scarring to ensure adequate injury.”
Karolinska Institute, Sweden National Institute of Neurological Disorders and Stroke 2023: $272,523 Changes in operation of postural networks in rabbits with postural functions recovered after lateral hemisection of the spinal cord. J. Physiol. 2023 Experimenters surgically implanted electrodes in eight rabbits’ legs, then cut their spinal cords. Then, experimenters cut the cerebrums from some rabbits’ brains, fixed the rabbits to a platform by their heads and vertebral columns, and tilted the platform to observe the rabbits’ muscle response.
Universidad Peruana Cayetano Heredia, Perú National Institute of Allergy and Infectious Diseases 2023: $134,720 Porcine model of neurocysticercosis by intracarotid injection of Taenia solium oncospheres: Dose assessment, infection outcomes and serological responses. PLoS Negl. Trop. Dis. 2022 Experimenters surgically implanted a catheter in the carotid arteries of 31 piglets so they could insert up to 10,000 tapeworm embryos. “Two pigs were euthanized … due to gastric torsion and severe pneumonia.” The remaining piglets were killed five months after the surgery.
University College London, U.K. NIH Office of the Director 2021: $853,638 Simplifying the hardware requirements for fast neural EIT of peripheral nerves. Physiological Measurement. 2022   Fascicle localisation within peripheral nerves through evoked activity recordings: A comparison between electrical impedance tomography and multi-electrode arrays. J. Neurosci. Methods. 2021   Optimization of the electrode drive pattern for imaging fascicular compound action potentials in peripheral nerve with fast neural Electrical Impedance Tomography (EIT). Physiol. Meas. 2019 Experimenters cut rats open, dissected their sciatic nerve, implanted electrodes, and killed the animals.
Kenyatta University, Kenya National Institute of Allergy and Infectious Diseases 2023: $156,736 Characterisation of drug resistance in field-collected schistosomes. [Grant] Experimenters infect hamsters with a parasite that causes the devastating  disease schistosomiasis, whose symptoms include fever, chills, and muscle aches.
University of Strasbourg, France National Institute on Alcohol Abuse and Alcoholism 2023: $255,960 The GPR88 agonist RTI‐13951‐33 reduces alcohol drinking and seeking in mice. Addict. Biol. 2022 Experimenters addicted mice to morphine and alcohol.
McGill University, Canada National Institute on Drug Abuse 2023: $258,140 Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice. Nat. Commun. 2023 Experimenters gave young mice “recreational-like” and “Adderall-like” doses of amphetamines, injected viruses into their brains, and decapitated them weeks later.
University of Helsinki, Finland National Institute of Neurological Disorders and Stroke 2021: $422,943 Capturing large-scale locus coeruleus single neuron activity in behaving rats with nanoelectronic threads (NETs), an ultra-flexible multi-electrode probe. [Grant] Experimenters restrain fully awake rats, implant more than 500 electrodes in their brains, and force the animals to live like this for months.
C4X Discovery Holdings PLC, U.K. National Institute on Drug Abuse 2018: $476,025 Preclinical development of a selective Orexin-1 receptor antagonist for treatment of cocaine addiction. [Grant] Experimenters addict rats to cocaine.
University of British Columbia, Canada National Eye Institute 2017: $267,961 Localization and functional characterization of the p.Asn965Ser (N965S) ABCA4 variant in mice reveal pathogenic mechanisms underlying Stargardt macular degeneration. Hum. Mol. Genet. 2018 Experimenters removed the eyes of baby mice.
University Health Network, Canada National Institute of Neurological Disorders and Stroke 2017: $846,905 Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke. Sci. Transl. Med. 2021 Experimenters caused strokes in rats and monkeys. Some animals died within 18 to 24 hours while others hemorrhaged between the brain and brain tissue.
Institut Pasteur de Tunis, Tunisia National Institute of Allergy and Infectious Diseases 2017: 112,335 Impact of zooprophylaxis on zoonotic cutaneous leishmaniasis transmission. [Grant] Experimenters use rabbits as bait for sandflies.
University of Calgary, Canada Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020: $53,973 An animal model for identifying regulatory sequences of the human SHOX gene. [Grant] Experimenters manipulate cats’ genes to create leg deformities.
Fondation Voir et Entendre, France National Eye Institute 2019: $214,941 Inducible nonhuman primate models of retinal degeneration for testing end-stage therapies. Sci. Adv. 2023 Experimenters caused the pupils of mice and monkeys to become dilated and forced the animals to keep their eyes open while injecting a “viral vector solution” into their eyes “to create a bleb.” Other mice and monkeys’ pupils were also dilated, and they were forced to keep their eyes open for hours while being directly exposed to light. Experimenters also cut open the eyes of rats and monkeys, detached their retinas, and implanted a patch in their eyes. Rats used to test a patch material experienced “massive physical damage and inflammation in the surgery location and surrounding areas.” Finally, the experimenters removed all the animals’ eyes.
Centre for the AIDS Programme of Research, South Africa National Institute of Allergy and Infectious Diseases 2016: $171,641 Integrin a4b7 as a predictor of HIV acquisition and pathogenesis. [Grant] Experimenters infect monkeys with simian immunodeficiency virus—an illness in monkeys that’s not the same as HIV.
Universitätsklinikum Erlangen, Germany National Institute of Allergy and Infectious Diseases 2019: $178,041 Global panel of non-human primate challenge viruses for standardized assessment of in vivo efficacy of HIV-1 Env antibodies. [Grant] Experimenters infect monkeys with simian immunodeficiency virus and other viruses.
Vaxine Pty Ltd, Australia National Institute of Allergy and Infectious Diseases 2020: $3,532,876 Advanced development of vaccine candidates for biodefense and emerging infectious diseases. [Grant] Experimenters inject monkeys with influenza vaccines.
The Centre for Addiction and Mental Health, Canada National Institute of Mental Health 2017: $154,967 Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder. Neuropharmacology. 2020   Prefrontal cortex deep brain stimulation improves fear and anxiety-like behavior and reduces basolateral amygdala activity in a preclinical model of posttraumatic stress disorder. Neuropsychopharmacology. 2018 Experimenters electroshocked rats to induce “fear and anxiety,” drilled holes in their skulls, and implanted electrodes in their brains. Finally, they killed the animals.
McMaster University, Canada National Institute of Mental Health 2019: $633,250 Transcriptional markers of excitation-inhibition balance in germ-free mice show region-specific dysregulation and rescue after bacterial colonizationJ. Psychiatr. Res. 2021 Experimenters force-fed human feces to mice, then killed them and removed their brains.
Hamilton Health Sciences Corporation, Canada National Institute of General Medical Sciences 2023: $325,999 National Institute on Aging 2023: $332,452 Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalkCell. Rep. 2024 Experimenters burned mice over 20–30% of their bodies, cut open their stomachs to extract fat tissue, and transplanted the tissue into “recipient mice.” Three weeks later, the mice were killed.
University of Calgary, Canada National Institute of Neurological Disorders and Stroke 2023: $270,000 Transmission of cervid prions to humanized mice demonstrates the zoonotic potential of CWD. Acta. Neuropathol. 2022 Experimenters injected brain or spinal cord tissue from a deer who died of chronic wasting disease (CWD) into the brains of female mice. Then, experimenters infected voles with feces and brain tissue obtained from the infected mice. Experimenters left the mice and voles to reach the “terminal stage of disease,” in which they experienced involuntary muscle twitching or jerking, “rigid tail, rough coat, gait abnormalities, ataxia [loss of muscle control], kyphosis [hunched back], and cycles of weight loss and gain.” Two of the mice were found dead. According to the grant submitted by the experimenters to NIH, they’re planning to infect monkeys, too.
Trinity College Dublin, Ireland National Institute on Aging 2020: $153,231 Susceptibility to acute cognitive dysfunction in aged mice is underpinned by reduced white matter integrity and microgliosisCommun. Biol. 2024 Experimenters infected mice with bacterial endotoxin to make them sick, forced them to perform cognitive tests, and killed them.
Ross University School of Veterinary Medicine, St. Kitts, West IndiesNational Institute of Allergy and Infectious Diseases 2023: $53,676 Susceptibility of African green monkeys (Chlorocebus aethiops sabaeus) to Rickettsia felis, the agent of flea-borne spotted fever. [Grant] Experimenters infect monkeys with the bacteria that causes typhus, whose symptoms include fever, muscle and joint pain, rash, headache, and fatigue.
Inserm Strasbourg, France National Institute on Drug Abuse 2023: $270,000 Habenular neurons expressing mu opioid receptors promote negative affect in a projection-specific mannerBiol. Psychiatry. 2023 Experimenters cut open the skulls of mice, injected them with a virus, and implanted an optical cord in their brains. “From a total of 108, 43 mice were excluded from analysis due to incorrect virus injection or cannula placement.” Experimenters then subjected the mice to “behavioral testing” that included being suspended by their tails for six minutes. Then, the experimenters exposed the mice to light for three minutes and killed them.
Pluri Inc. (formerly known as Pluristem Therapeutics), Israel National Institute of Allergy and Infectious Diseases 2023: $1,445,145 Development of PLX-R18 cell therapy as a countermeasure for hematopoietic acute radiation syndrome. [Grant] Experimenters subject mice and monkeys to whole-body radiation, which can cause anorexia, severe nausea, vomiting, cramps, and diarrhea as well as result in death due to infection and hemorrhage.

 

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