| Institution conducting experiment, country, funding agency, and award | Grant or published paper | What experimenters do/did to animals |
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Kinoxis Therapeutics, Australia National Institute on Drug Abuse 2023: $2,149,117 |
Advancing KNX100 for the treatment of opioid withdrawal: preclinical efficacy and toxicology, and a phase 1 clinical program. [Grant] | Experimenters addict dogs to opioids. |
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University of Prince Edward Island, Canada National Institute of Neurological Disorders and Stroke 2023: $138,116 |
Early-life seizures modify behavioral response to ultrasonic vocalization playback in adult rats. Epilepsy Behav. 2022 | Experimenters injected acid into the brains of baby rats to induce seizures. |
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University of Calgary, Canada National Institute of Allergy and Infectious Diseases 2023: $602,472 |
Utility of hybrid transferrin binding protein antigens for protection against pathogenic neisseria species. Front Immunol. 2019 | Experimenters infected 48 female mice with gonorrhea and 32 male mice with bacterium that cause meningitis. |
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University of Melbourne, Australia National Institute of Diabetes and Digestive and Kidney Diseases 2023: $321,387 |
Sex differences in c‐Fos and EGR‐1/Zif268 activity maps of rat sacral spinal cord following cystometry‐induced micturition. J. Comp. Neurol. 2021 | Experimenters surgically implanted catheters in the bladders of 24 rats, then infused saline solution into the bladders to force the animals to urinate constantly. |
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Commonwealth Scientific and Industrial Research Organization, Australia National Institute of Allergy and Infectious Diseases 2023: $146,098 |
Shining a light on bat cellular immunity following virus infection. [Grant] | Experimenters infect bats with a highly harmful virus. |
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University of Sydney, Australia National Institute of Allergy and Infectious Diseases 2022: $2,453,560 |
Advancing vaccine adjuvant research for tuberculosis (Avart-t). [Grant] | Experimenters infect monkeys with tuberculosis. |
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Newcastle University, U.K. National Institute of Neurological Disorders and Stroke 2023: $457,675 |
Locating the neural substrates for the flexor synergy after stroke. [Grant] | Experimenters surgically implant electrodes in monkeys’ arms and then damage their brains to strokes. |
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McGill University, Canada National Institute on Deafness and Other Communication Disorders 2023: $492,583 |
Functional analysis of injectable substance treatment on surgically injured rabbit vocal folds. J. Voice. 2021 | Experimenters cut the vocal cords of 12 rabbits and insert a spatula “several times to exacerbate inflammation and scarring to ensure adequate injury.” |
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Karolinska Institute, Sweden National Institute of Neurological Disorders and Stroke 2023: $272,523 |
Changes in operation of postural networks in rabbits with postural functions recovered after lateral hemisection of the spinal cord. J. Physiol. 2023 | Experimenters surgically implant electrodes in eight rabbits’ legs, then cut their spinal cords. Then, experimenters cut the cerebrums from some rabbits’ brains, fix the rabbits to a platform by their heads and vertebral columns, and tilt the platform to observe the rabbits’ muscle response. |
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Universidad Peruana Cayetano Heredia, Perú National Institute of Allergy and Infectious Diseases 2023: $134,720 |
Porcine model of neurocysticercosis by intracarotid injection of Taenia solium oncospheres: Dose assessment, infection outcomes and serological responses. PLoS Negl. Trop. Dis. 2022 | Experimenters surgically implanted a catheter in the carotid arteries of 31 piglets so they could insert up to 10,000 tapeworm embryos. “Two pigs were euthanized … due to gastric torsion and severe pneumonia.” The remaining piglets were killed five months after the surgery. |
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University College London, U.K. NIH Office of the Director 2021: $853,638 |
Simplifying the hardware requirements for fast neural EIT of peripheral nerves. Physiological Measurement. 2022
Fascicle localisation within peripheral nerves through evoked activity recordings: A comparison between electrical impedance tomography and multi-electrode arrays. J. Neurosci. Methods. 2021
Optimization of the electrode drive pattern for imaging fascicular compound action potentials in peripheral nerve with fast neural Electrical Impedance Tomography (EIT). Physiol. Meas. 2019 |
Experimenters cut rats open, dissected their sciatic nerve, implanted electrodes, and killed the animals. |
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Kenyatta University, Kenya National Institute of Allergy and Infectious Diseases 2023: $156,736 |
Characterisation of drug resistance in field-collected schistosomes. [Grant] | Experimenters infect hamsters with a parasite that causes the devastating disease schistosomiasis, whose symptoms include fever, chills, and muscle aches. |
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University of Strasbourg, France National Institute on Alcohol Abuse and Alcoholism 2023: $255,960 |
The GPR88 agonist RTI‐13951‐33 reduces alcohol drinking and seeking in mice. Addict. Biol. 2022 | Experimenters addicted mice to morphine and alcohol. |
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McGill University, Canada National Institute on Drug Abuse 2023: $258,140 |
Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice. Nat. Commun. 2023 | Experimenters gave young mice “recreational-like” and “Adderall-like” doses of amphetamines, injected viruses into their brains, and decapitated them weeks later. |
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University of Helsinki, Finland National Institute of Neurological Disorders and Stroke 2021: $422,943 |
Capturing large-scale locus coeruleus single neuron activity in behaving rats with nanoelectronic threads (NETs), an ultra-flexible multi-electrode probe. [Grant] | Experimenters restrained fully awake rats, implanted more than 500 electrodes in their brains, and forced the animals to live like this for months. |
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C4X Discovery Holdings PLC, U.K. National Institute on Drug Abuse 2018: $476,025 |
Preclinical development of a selective Orexin-1 receptor antagonist for treatment of cocaine addiction. [Grant] | Experimenters addicted rats to cocaine. |
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University of British Columbia, Canada National Eye Institute 2017: $267,961 |
Localization and functional characterization of the p.Asn965Ser (N965S) ABCA4 variant in mice reveal pathogenic mechanisms underlying Stargardt macular degeneration. Hum. Mol. Genet. 2018 | Experimenters removed the eyes of baby mice |
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University Health Network, Canada National Institute of Neurological Disorders and Stroke 2017: $846,905 |
Plasmin-resistant PSD-95 inhibitors resolve effect-modifying drug-drug interactions between alteplase and nerinetide in acute stroke. Sci. Transl. Med. 2021 | Experimenters caused strokes in rats and monkeys. Some animals died within 18 to 24 hours while others hemorrhaged between the brain and brain tissue. |
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Institut Pasteur de Tunis, Tunisia National Institute of Allergy and Infectious Diseases 2017: 112,335 |
Impact of zooprophylaxis on zoonotic cutaneous leishmaniasis transmission. [Grant] | Experimenters used rabbits as bait for sandflies. |
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University of Calgary, Canada Eunice Kennedy Shriver National Institute of Child Health and Human Development 2020: $53,973 |
An animal model for identifying regulatory sequences of the human SHOX gene. [Grant] | Experimenters manipulated cats’ genes to create leg deformities. |
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Fondation Voir et Entendre, France National Eye Institute 2019: $214,941 |
Translational models of photoreceptor degeneration to test safety and efficacy of stem celltransplantation. [Grant] | Experimenters injured monkeys’ eyes to blind them. |
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Centre for the AIDS Programme of Research, South Africa National Institute of Allergy and Infectious Diseases 2016: $171,641 |
Integrin a4b7 as a predictor of HIV acquisition and pathogenesis. [Grant] | Experimenters infected monkeys with simian immunodeficiency virus—an illness in monkeys that’s not the same as HIV. |
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Universitätsklinikum Erlangen, Germany National Institute of Allergy and Infectious Diseases 2019: $178,041 |
Global panel of non-human primate challenge viruses for standardized assessment of in vivo efficacy of HIV-1 Env antibodies. [Grant] | Experimenters infected monkeys with simian immunodeficiency virus and other viruses. |
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Vaxine Pty Ltd, Australia National Institute of Allergy and Infectious Diseases 2020: $3,532,876 |
Advanced development of vaccine candidates for biodefense and emerging infectious diseases. [Grant] | Experimenters injected monkeys with influenza vaccines. |
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Centre for Addiction And Mental Health, Canada National Institute of Mental Health 2017: $154,967 |
Endocannabinoid modulating drugs improve anxiety but not the expression of conditioned fear in a rodent model of post-traumatic stress disorder. Neuropharmacology. 2020
Prefrontal cortex deep brain stimulation improves fear and anxiety-like behavior and reduces basolateral amygdala activity in a preclinical model of posttraumatic stress disorder. Neuropsychopharmacology. 2018 |
Experimenters electroshocked rats to induce “fear and anxiety,” drilled holes in their skulls, and implanted electrodes in their brains. Finally, they killed the animals. |
