| TESTS |
# ANIMALS |
| Acute oral toxicity (rat) |
5-7 |
| Acute inhalation toxicity (rat) |
20 |
| Acute dermal toxicity (rat) |
20 |
| Eye irritation (rabbit) |
3 |
| Skin irritation (rabbit) |
3 |
| Skin allergy (mouse and/or guinea pig) |
16-30 |
| 28-day dermal toxicity (rat) |
40 |
| 90-day feeding study (rat) |
120 |
| 90-day feeding study (dog) |
32 |
| 90-day inhalation study (rat) |
80 |
| Lifetime feeding study (rat) |
160 |
| Lifetime feeding study (dog) |
32 |
| Genetic toxicity (mouse micronucleus) |
80 |
| Genetic toxicity (chromosomal aberration) |
80 |
| Cancer effects (rat) |
400 |
| Cancer effects (mouse) |
400 |
| Acute nervous system toxicity (rat) |
60 |
| Acute delayed nervous system toxicity (hen) |
80 |
| 90-day nervous system toxicity (rat) |
60 |
| 90-day nervous system toxicity (hen) |
80 |
| Developmental nervous system toxicity |
1,300 |
| Reproductive toxicity in two generations (rat) |
2,500 |
| Birth defects (rat) |
1,300 |
| Birth defects (rabbit) |
900 |
| Immune system toxicity (rat) |
32 |
| General metabolism (rat) |
24 |
| Skin penetration (rat) |
24 |