There's a humane way to do anything! According to Dr. David E. Davis of Johns Hopkins University, "Poisons or traps merely make space for more rats to grow." To prevent a rat or mouse problem, take away what makes your home attractive to them: food and shelter.
Start by making sure that there is no food in open places or in cardboard containers, which rats can eat right through. Keep garbage in tightly covered containers. Next, deny them a way to enter your home by sealing holes at the bottom of walls. Of course, this means that while no rats can come in, any who are already inside can't get out.
If rats are already inside, you will need to set a trap—but be careful which one you pick. Glue traps,
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